Vivekanandha
College of Arts and Sciences for Women (Autonomous)
'A+' Grade by NAAC || ISO 9001:2015 Certified
DST-FIST & DST-PG CURIE Sponsored
Approved by UGC Act 1956 under Section 2(f)&12(B) and AICTE
Affiliated to Periyar University, Salem
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E-CONTENT OF PG & RESEARCH DEPARTMENT OF BIOCHEMISTRY
| SUBJECT CODE: 18P1BC02 SUBJECT NAME: CELLULAR BIOCHEMISTRY |
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| Unit I - Cellular Organelles: Definition, Structure and functions of cells-prokaryotes and eukaryotes, Morphology and function of Cytoplasm, endoplasmic reticulum, ribosomes, golgi apparatus, lysosomes, mitochondria, nucleus, chromosomes, chromosome organization , centrioles, chloroplasts, peroxisomes and glyoxysomes; Intracellular compartments and protein sorting , Intracellular vesicular traffic, autocrine, paracrine and endocrine. • http://www.lcwu.edu.pk/ocd/cfiles/Botany/Maj/Bot%20-201/Ultrastructureofcell.pdf • http://salahmartin.yolasite.com/resources/BIO_201/Golgi%20App.pdf • https://lecerveau.mcgill.ca/flash/capsules/articles_pdf/cytoskeleton.pdf • https://www.bemidjistate.edu/academics/departments/science/k12-science-units/Celll-theoy-and-organelles-biology.pdf • http://www.biologymad.com/resources/AS%20Cells.pdf • https://www.lkouniv.ac.in/site/writereaddata/siteContent/202004021912558194monisha_Protein_Targeting.pdf • https://www.theexpertta.com/book-files/OpenStaxBio2e/Chapter%209%20-%20Cell%20Communication.pdf |
| Unit II – Cell cycle: Cell division - mitosis and meiosis, cell cycle - phases of cell cycle, and regulation of cell growth and cell cycle, Cytoskeleton - Structure and composition of cytoskeleton, Actin filament, intermediate filament and microtubule, Self assembly and dynamic structure of cytoskeletal filaments, regulation of cytoskeletal filaments, Molecular motor, Cytoskeleton and cell behaviour, molecular motors, micro tubular associated proteins - role in intracellular motility • http://www.bio.brandeis.edu/classes/heredity/Lecture%20Powerpoints/chapter8.pdf • https://www2.le.ac.uk/projects/oer/oers/genetics/oers/The%20cell%20cycle/The%20cell%20cycle-TRF.pdf • http://ccnet.vidyasagar.ac.in:8450/pluginfile.php/1152/mod_resource/content/2/Cytoskeletal%20system.pdf • https://www.andrew.cmu.edu/course/42-620/handouts/BME_42_620_Lecture_12_2011.pdf • https://www.ncbi.nlm.nih.gov/books/NBK21710/ |
| Unit III – Cellular Interaction and signaling : Cell-Cell interaction - Collagen, hyaluronan & proteoglycans, laminin, integrins and fibronectins, Cell-Cell adhesion - Specialised junctions, Desmosomes, Gap junctions, Adhesion molecules – Cadherins, Connexins. Cell-Cell signaling – Types, Cell Signaling molecules and their receptors, functions of cell surface receptors, pathways, intra and extracellular signal transduction and second messengers (G –protein coupled receptors, receptor tyrosine kinases), cAMP, cGMP • http://www.cusb.ac.in/images/cusb-files/2020/el/bis/cell_cell_interaction.pdf • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185430/ • https://www.slideshare.net/Saradbrata/extracellular-matrix-61821362 • https://www.lab.anhb.uwa.edu.au/hb308/PDFs/cell%20adhesion%20molecules%20300107.pdf • https://www.dacollege.org/smat/zoo-sem2-cell-junction.pdf • http://mcb.berkeley.edu/courses/mcb110spring/nogales/mcb110_s2008_4signaling.pdf • http://dosequis.colorado.edu/Courses/MCDB3145/Docs/Karp-617-660.pdf |
| Unit IV – Programmed Cell Death and cancer signaling : cell growth and apoptosis, Apoptosis – PI3K-Akt, NF-KB, Ras-Erk IGF-1 and NOTch signaling Pathways, regulators, effectors in apoptosis, oncology: oncogenes, causes, malignant non-malignant tumor, Properties of tumor cells, Tumor suppressor genes, human chorionic gonadotropin, cancer antigen 125, carcinoembryonic antigen (CEA), prostate-specific antigen, alpha-fetoprotein cancer markers. Carcinogenic effect of chemicals and radiation. Methods of studying the cell surface, re-constitutional studies; fluorescence assisted methods e.g. flow cytometry • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665079/ • http://www.dbm.ufpb.br/~marques/Artigos/Cell%20cycle%20and%20apoptosis.pdf • https://www.patnauniversity.ac.in/e-content/science/zoology/MScZoo45.pdf • https://www.ncbi.nlm.nih.gov/books/NBK21662/ • https://pubmed.ncbi.nlm.nih.gov/19383238/ • https://en.wikipedia.org/wiki/Carcinogen • https://www.cytometry.uzh.ch/dam/jcr:69e392cd-50de-4d8d-87f2-4a5248077493/Basics%20of%20Fluorescence-Assisted%20Cell%20Sorting%20Seminar2017%20handouts.pdf |
| Unit V – Membrane Architecture and Functions: Membrane bilayer - Models, Membrane lipids - fluidity, Asymmetry phase transition, Liposomes Membrane proteins - Types, Orientation, Bacteriorhodopsin, Porins-aquaporin, RBC ghosts, solubilisation of proteins, lipid anchored proteins carbohydrates and cell surface carbohydrates – Lectins, Membrane transport - ion channels, symporters and antiporters, Transport of water, glucose and amino acids. • http://cytochemistry.net/cell-biology/membrane.htm#:~:text=Membranes%20are%20vital%20because%20they,and%20organelles%20of%20a%20cell. • http://www.sci.sdsu.edu/tfrey/Biology203/Ch7MembraneStruct.pdf • https://openbiologyjournal.com/contents/volumes/V6/TOBIOJ-6-14/TOBIOJ-6-14.pdf • https://bio.libretexts.org/Bookshelves/Biochemistry/Book%3A_Biochemistry_Free_For_All_(Ahern_Rajagopal_and_Tan)/03%3A_Membranes/3.02%3A_Transport_in_Membranes • https://en.wikipedia.org/wiki/Porin_(protein) • https://en.wikipedia.org/wiki/Aquaporin |